Abstract #0179

Evaluation of a cervical cancer-specific restriction spectrum imaging model on an independent pilot cohort using PET/MRI: pre- and post-therapy

Elin Lundström^1,2,3, Ana E Rodríguez-Soto¹, Elisabeth Hedlund³, Björg Jónsdóttir⁴, Katarzyna Kozar³, Christopher Conlin¹, Stephane Loubrie¹, Stephan Jordan¹, Alexandra Schlein¹, Sheida Ebrahimi¹, J Stefan Peterson⁵, Arnaud Guidon⁶, Joshua Kuperman¹, Tyler M Seibert^1,7,8, Anders Dale^1,9, Per Liss^2,3, Anthoula Koliadi^10,11, and Rebecca Rakow-Penner¹

¹Department of Radiology, University of California San Diego, La Jolla, CA, United States, ²Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, ³Center for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden, ⁴Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden, ⁵GE Healthcare, Stockholm, Sweden, ⁶Global MR Application and Workflow, GE Healthcare, Boston, MA, United States, ⁷Department of Radiation Medicine, University of California San Diego, La Jolla, CA, United States, ⁸Department of Bioengineering, University of California San Diego, La Jolla, CA, United States, ⁹Department of Neuroscience, University of California San Diego, La Jolla, CA, United States, ¹⁰Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ¹¹Department of Oncology, Uppsala University Hospital, Uppsala, Sweden

Synopsis

Keywords: Pelvis, Diffusion/other diffusion imaging techniques, restriction spectrum imaging, cervical cancer

Motivation: Restriction spectrum imaging (RSI) can potentially improve cervical cancer evaluation pre- and post-therapy, particularly in separating persistent malignancy from post-treatment edema.

Goal(s): To evaluate a cervical cancer-specific RSI model for assessment on an independent pilot cohort examined with combined PET/MRI.

Approach: Four patients underwent PET/MRI before (chemo)radiotherapy. Two of them also underwent PET/MRI within 4 weeks of treatment, MRI 3 months post-treatment and PET/MRI 6 months post-treatment. Two healthy volunteers underwent MRI only.

Results: Preliminary results showed increased tumor conspicuity on RSI compared to conventional pre-therapy PET/MRI and promising results early post-therapy.

Impact: Cervical cancer-specific restriction spectrum imaging (RSI), evaluated on an independent pilot cohort, indicates increased tumor conspicuity compared to conventional pre-therapy PET/MRI and promising results post-therapy. Future work will target early therapy response assessment in combined RSI-PET/MRI at a larger scale.

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