Abstract #0187

Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation

Jayvik Joshi¹, Minmin Yao^2,3, Wenzhen Duan^2,3, and Manisha Aggarwal⁴

¹Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ²Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Susceptibility/QSM, Microstructure, Brain

Motivation: Susceptibility source separation methods to disentangle sub-voxel paramagnetic and diamagnetic susceptibility sources may provide higher specificity to distinguish tissue microstructural alterations.

Goal(s): Our goal was to investigate sub-cellular histopathological alterations in an established tauopathy mouse model using quantitative susceptibility source separation.

Approach: Brains of PS19 mice and wild-type controls (n = 5 each) were imaged at 11.7 T. We used the DECOMPOSE-QSM model to calculate paramagnetic and diamagnetic component susceptibility maps.

Results: Susceptibility maps revealed significant localized alterations in specific regions of the hippocampus and entorhinal cortex, which were found to correspond to regional microgliosis and tau deposition seen with immunohistology.

Impact: Our findings demonstrate unique sensitivity of paramagnetic and diamagnetic susceptibility changes to distinguish regional microgliosis and tau deposition in the brain. Quantitative magnetic susceptibility source separation may therefore provide a sensitive method to assess sub-cellular histopathological alterations in tauopathies.

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