Keywords: Susceptibility/QSM, Quantitative Susceptibility mapping, Susceptibility separation, R2*, SWI, MPRAGE, single-echo GRE
Motivation: Susceptibility separation enables exploring sub-voxel contributions of iron/myelin but requires multi-echo gradient-echo to calculate the R2* map. Extending its applicability to single-echo measurements such as in SWI-focused studies, would allow wider usage.
Goal(s): To develop and validate at 3T an approach that produces brain para- and diamagnetic maps from SWI with information from MPRAGE images typically collected for structural imaging.
Approach: R2* was estimated from SWI and MPRAGE using Bloch simulations, followed by production of para- and diamagnetic maps using calculated R2* and R2 maps, and SWI phase.
Results: Comparable maps to those produced from multi-echo images were obtained.
Impact: The proposed method enables producing para- and diamagnetic maps from SWI studies, with the possibility of retrospective application if SWI raw phase and T1w images exist.
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