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Abstract #0200

Value of quantitative relaxation mapping calculated from Multiple-Repetition Multiple-Echo DWI acquisition in prostate cancer detection

Tsutomu Tamada1, Yu Ueda2, Mitsuru Takeuchi3, Atsushi Higaki4, Yuichi Kojima4, Yoshihiko Fukukura4, and Akira Yamamoto4
1Radiology, Kawasaki Medical School, Kurashiki, Japan, 2Philips Japan, Tokyo, Japan, 3Radiolonet Tokai, Nagoya, Japan, 4Kawasaki Medical School, Kurashiki, Japan

Synopsis

Keywords: Prostate, Prostate

Motivation: The detection rate of csPCa in PI-RADS 3 lesions is only 25-38%. This leads to unnecessary biopsies.

Goal(s): Can multiparametric quantitative maps based on estimated T1 and T2 help differentiate clinically significant prostate cancer (csPCa) from non-csPCa in PI-RADS 3 lesions?

Approach: We compare T1, T2, and ADC obtained from Multiple-Repetition time Multiple- Echo time (MRME) based DWI (MRME-DWI) between csPCas and non-csPCas in PI-RADS 3 lesion using MRI-ultrasound fusion targeted biopsy as the reference standard.

Results: The T1, T2, and ADC were significantly lower for csPCas than non-csPCas. Combining these indices yields an AUC of 0.82.

Impact: MRME-DWI can simultaneously obtain T1, T2, and ADC from a single region of interest in a single imaging session. Combining these quantitative measures is expected to improve the detection rate of clinically significant prostate cancer in PI-RADS 3 lesions.

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Keywords

prostateradslesionscancerbiopsyclinicallyquantitativeproventargetrepetitionjapanacquisitionsynthetizationdetectiondifferentiate