Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)
Motivation: Human hyperpolarized metabolic imaging relies upon unstable exogenous radicals like the trityl radical EPA, necessitating clean rooms, pharmacy staff, and filters.
Goal(s): We wished to avoid EPA by using an ultrahigh-dose-rate 6 MeV electron accelerator, generating endogenous [1-13C]alanine radicals for DNP.
Approach: We studied irradiated samples up to 100 kGy at two polariser field-strengths (3.35/6.7T), characterised radical species formed by EPR, X-ray diffraction, and numerical quantum-mechanical simulations.
Results: Radicals from biologically sterilising doses were stable for months when stored anhydrously, quenching rapidly with dissolution. Comparable nuclear polarisation to pyruvate at 6.7T was observed in a partially-ordered glycerol/alanine mix, potentially via a cross-effect mechanism.
Impact: This has several novel impacts – it: (1) makes centralised manufacturing & storage possible with dual-purpose irradiation sterilising a sealed fluid-path; (2) demonstrates electron irradiation feasible for DNP; and (3) highlights how molecular environments could be partially controlled for polarisation optimisation.
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