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Abstract #0221

First-in-Human Whole-Abdomen Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate in D2O and Initial Application in Human Pancreatic Cancer

Guannan Zhang1, Kofi Deh1, Hijin Park2, Charles Cunningham3,4, Nadia Bragagnolo3, Serge Lyashchenko2, Shake Ahmmed2, Avigdor Leftin5, Elizabeth Coffee6, Hedvig Hricak7, Vesselin Miloushev7, Marius Mayerhoefer1, and Kayvan Keshari7
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiochemistry and Molecular Imaging Probes (RMIP) Core, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 4Sunnybrook Research Institute, Toronto, ON, Canada, 5GE HealthCare, New York, NY, United States, 6Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 7Department of Radiology & Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), whole-abdomen imaging, hyperpolarized [1-13C]pyruvate, deuterium oxide (D2O), pancreatic ductal adenocarcinoma (PDAC)

Motivation: Whole-abdomen imaging with hyperpolarized [1-13C]pyruvate holds promise to diagnose metabolic diseases. D2O solvation could extend the 13C T1 lifetime, resulting in enhanced image SNR.

Goal(s): Establish the safety and feasibility of utilizing D2O to administer hyperpolarized [1-13C]pyruvate in whole-abdomen imaging, and present the first application of whole-abdomen hyperpolarized [1-13C]pyruvate MRI in a PDAC patient.

Approach: We quantified the metabolic characteristics of organs in healthy and diseased subjects.

Results: The use of D2O is safe and feasible. It has no significant impact on organ metabolism and delivery of the pyruvate bolus. This technique demonstrates potential for application in cancer patients.

Impact: The safety and feasibility of employing D2O for hyperpolarized 13C whole-abdomen MRI sets the stage for translational studies. The first application of hyperpolarized whole-abdomen [1-13C]pyruvate MRI to a PDAC patient provides essential support for its future exploration in oncology.

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Abstract

Keywords