Keywords: Deuterium, Deuterium, Glucose Metabolic Rates
Motivation: Cerebral glucose metabolism via non-oxidative and oxidative pathways is critical for brain function, however, methods capable of quantitatively imaging metabolic rates are lacking.
Goal(s): To develop a quantitative dynamic deuterium (2H) MRSI (DMRSI) method capable of mapping human brain glucose metabolic rates.
Approach: Combining novel hardware and advanced post-processing method with kinetic models, we established a high-resolution, high-quality dynamic DMRSI capable of quantifying and imaging three metabolic rates of glucose consumption (CMRGlc), lactate generation (CMRLac) and TCA cycle (VTCA) in human brain at 7T.
Results: We demonstrate consistent whole-brain maps of CMRGlc, CMRLac, VTCA in health subjects.
Impact: We developed a novel DMRSI platform on an FDA-approved clinical 7T scanner that enables simultaneous high-resolution imaging of CMRGlc, CMRLac and VTCA of entire human brain for the first time. This novel technology has potential for brain research and translation.
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