Keywords: Deuterium, Deuterium
Motivation: Formate overflow linked to mitochondrial oxidative serine catabolism has been observed in various forms of cancer, and there is evidence that elevated formate concentrations promote cell infiltration.
Goal(s): Our goal was to monitor serine catabolism using deuterium metabolic imaging.
Approach: Cell experiments were conducted using a 14.1 T high-resolution NMR spectrometer and 2H experiments on tumors in vivo using a 7.0 T horizontal bore magnet.
Results: [2,3,3-2H2]serine catabolism can be monitored directly from measurements of 2H-formate production and indirectly from 2H-labeling of water.
Impact: Monitoring [2,3,3-2H2]serine metabolism holds huge potential when assessing novel cancer treatments that target the one-carbon pathway to inhibit tumor cell proliferation.
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