Keywords: Biology, Models, Methods, Deuterium, Deuterium metabolic imaging; Intracerebral hemorrhage; Lactate
Motivation: Lactate, as an important metabolism product after intracerebral hemorrhage (ICH), plays a crucial role in the pathophysiology and prognosis. Deuterium metabolic imaging (DMI), as a potentially transformative technique, can localize abnormal metabolism associated with lactate.
Goal(s): Optimize deuterium coils and sequences to improve the signal-to-noise ratio of DMI, and quantitatively analyze lactate changes after ICH with optimized techniques.
Approach: Propose the active decoupling 2H/1H dual-tuned transceiver coil and CSI-bSSFP sequence for DMI and measure the dynamical lactate metabolism in three groups of rats before and after ICH.
Results: DMI can measure the lactate metabolic changes at different time points after ICH.
Impact: This study presents a non-invasive technique for monitoring the lactate metabolic changes after ICH, which holds clinical potential in determining the time of onset, treatment plan, and real-time response evaluation.
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