Abstract #0252

Metabolite-cycling at 14.1T: sequence implementation and initial explorations using SPECIAL and diffusion-weighted SPECIAL

Jessie Mosso^1,2, André Döring^1,2, Roland Kreis^3,4, Cristina Cudalbu^1,2, and Bernard Lanz^1,2

¹CIBM Center for Biomedical Imaging, Lausanne, Switzerland, ²Animal Imaging and Technology, EPFL, Lausanne, Switzerland, ³Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, ⁴Translational Imaging Center, sitem-insel, Bern, Switzerland

Synopsis

Keywords: Spectroscopy, Brain, MRS, metabolite-cycling, sequence development, SPECIAL, diffusion, DW-MRS, downfield

Motivation: Water suppression leads to saturation of exchanging protons which biases metabolite concentration estimates and prevents the study of downfield resonances in the ¹H spectrum.

Goal(s): Apply metabolite-cycling (MC) to study these resonances with high sensitivity using the short-TE, full-intensity SPECIAL sequence at ultra-high field on an animal scanner.

Approach: The MC pulse was optimized for 14.1T. MC SPECIAL and MC diffusion-weighted SPECIAL were implemented and tested in vivo.

Results: Underestimation of specific upfield metabolite concentrations with water-suppressed SPECIAL compared to MC SPECIAL was observed. Downfield resonances attribution was further validated with diffusion-weighted acquisitions, uniquely showing the presence of macromolecules in the 6.5-7.5ppm region.

Impact: The introduction of metabolite-cycling in the short echo-time, full intensity SPECIAL and diffusion-weighted SPECIAL ¹H MRS sequences at 14.1T paves the way for in-depth exploration of the downfield resonances of the ¹H spectrum with high sensitivity on animal scanners.

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