Abstract #0254

Multilayer Metabolic Networks of Mesial Temporal Lobe Epilepsy: Insights from Simultaneous PET/MRSI

Hui Huang¹, Miao Zhang², Yibo Zhao^3,4, Wen Jin^3,4, Yudu Li^3,5, Bingyang Cai¹, Jiwei Li¹, Zhi-Pei Liang^3,4, Biao Li², and Jie Luo¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁵National Center for Supercomputing Applications, University of Illinois at Urbana Champaign, Urbana, IL, United States

Synopsis

Keywords: Epilepsy, Metabolism, PET/MR

Motivation: How chronic epilepsy impacts the interplay between neuronal metabolites and inter-regional metabolic connectivity remains unclear.

Goal(s): To identify neurometabolic imaging biomarkers for epilepsy progression using PET/MRSI.

Approach: Forty-eight patients with drug-resistant mesial temporal lobe epilepsy and fifteen patients with extratemporal epilepsy underwent simultaneous high-resolution MRSI and FDG PET. Moderation effects of disease duration were evaluated for multiple brain regions; multilayer metabolic networks were constructed to investigate metabolic changes of NAA, FDG and their interplay.

Results: We found disease duration moderated changes in the interplay between NAA and FDG. Metabolic networks form distinct modules in short duration and long duration groups.

Impact: This is the first simultaneous PET/MRSI study to investigate multilayer metabolic network associated with disease duration of mTLE, which could offer a comprehensive view of neurometabolic profile, facilitating the exploration of imaging markers in epileptic lesion detection and disease progression.

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