Abstract #0260

Accelerated 3D Metabolite T1 Mapping Using Variable-Flip-Angle FID MRSI

Yibo Zhao^1,2, Rong Guo^1,3, Yudu Li^1,4, Wen Jin^1,2, Brad Sutton^1,4,5, Chao Ma⁶, Georges El Fakhri⁷, Yao Li⁸, Jie Luo⁸, and Zhi-Pei Liang^1,2

¹Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Siemens Medical Solutions USA, Inc., Urbana, IL, United States, ⁴National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁷Yale School of Medicine, New Haven, CT, United States, ⁸School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Synopsis

Keywords: Spectroscopy, Spectroscopy

Motivation: Metabolite T1 values are needed for T1 correction in short-TR MRSI data. Due to the prolonged scan time, metabolite T1 measurement has been limited to single-voxel or single-slice experiments so far.

Goal(s): To develop a novel method for 3D metabolite T1 mapping in a practically feasible scan time.

Approach: We used a variable-flip-angle short-TR MRSI to achieve rapid metabolite T1 mapping. The high-dimensional data space was undersampled in a variable-density manner. Associated data processing challenges were solved by generalized-series and low-rank-tensor modelling.

Results: Simulation, phantom and healthy subject results demonstrated the feasibility of accelerated 3D metabolite T1 mapping.

Impact: The proposed method enables 3D metabolite T1 mapping within a clinically feasible scan time (15 min). This method can be used to correct T1 weighting effects in accelerated short-TR MRSI experiments, producing more quantitative results.

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