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Abstract #0282

Ex-vivo 4D Flow MRI for Evaluation of Aortic Valve Pathologies in a Mock Circulatory System

Leah M Gober1, James Rice2, Michael Stellon1, and Alejandro Roldán-Alzate 2,3
1Surgery, University of Wisconsin-Madison, Madison, WI, United States, 2Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 3Radiology, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Valves, Velocity & Flow

Motivation: The Ross Procedure is a complex cardiac surgery that utilizes the pulmonary valve to replace a diseased aortic valve. More work is needed to improve preoperative candidacy.

Goal(s): To develop and validate an ex-vivo model of the aortic valve in combination with a mock circulatory system.

Approach: The left ventricle was mounted on a circulatory loop with preservation of aortic valve anatomy and application of hemodynamic flow to assess valve characteristics.

Results: A successful system was built and 4D Flow MRI performed with resultant functional quantification and representative curves mimicking ventricular inflow and aortic outflow.

Impact: 4D Flow MRI, in combination with an ex-vivo left ventricular mock circulatory system, provides a method to study aortic flow and assess valvular abnormalities or preoperative candidacy in cardiac surgery.

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