Keywords: Parkinson's Disease, Parkinson's Disease, susceptibility-weighted imaging; kinetics; iron accumulation; relaxometry covariance network; substantia nigra
Motivation: Iron deposition is implicated in the pathogenesis of Parkinson's disease (PD). However, most of the previous studies failed to report progressive iron accumulation with disease progression.
Goal(s): This study aimed to explore the kinetics of iron accumulation in the PD brain using a novel relaxometry covariance network (RCN) approach.
Approach: The RCN approach consisted of three steps, the identification of brain regions as propagators of iron, construction of causal RCN and individual differential RCN.
Results: The left substantia nigra pars reticulata, left substantia nigra pars compacta, and lobule VII of cerebellum vermis were identified as propagators of iron.
Impact: The application of our novel relaxometry covariance network on susceptibility-weighted imaging revealed iron accumulation kinetics in Parkinson's disease, which were closely related to the pathophysiological aspects of the disease. The current findings deserved further exploration to elucidate the underlying mechanisms.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords