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Abstract #0313

Multi-parametric radiomics of T1and susceptibility-weighted imaging for differentiating Parkinson’s disease and multiple system atrophy.

Shuting Bu1, Yueluan Jiang2, and Guoguang Fan3
1the First hospital of China Medical University, Shenyang,Liaoning, China, 2MR Research Collaboration, Siemens Healthineers, Beijing China, Beijing, China, 3the First hospital of China Medical University, Shenyang, China

Synopsis

Keywords: Radiomics, Neurodegeneration

Motivation: Aim to differentiate PD from MSA in the early stage.

Goal(s): To build a radiomic model based on features derived from basal ganglia regions by using commonly applied sequences in clinical settings, to distinguish between PD and MSA.

Approach: This study constructed three machine learning models- logistic regression, support vector machine and light gradient boosting method to differentiate PD motor subtypes.

Results: The light gradient boosting machine trained by features extracted from SWI and T1 sequences achieved a great classification performance between PD and MSA (AUC=0.881).

Impact: This study has developed an effective classification model using commonly utilized clinical MRI sequences, which provides a valuable tool for distinguishing between PD and MSA in clinical practice.

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Keywords