Keywords: Functional Connectivity, High-Field MRI, fMRI, interneuron, neurovascular coupling
Motivation: SST neurons, 30% of cortical interneurons, are crucial in interpreting fMRI data and understanding neurovascular coupling within the cortex.
Goal(s): In this study we want to investigate the the SST-induced hemodynamic response
Approach: we used several methods such as neural recording, BOLD-fMRI, and optical intrinsic signaling (OIS) with pharmacological applications.
Results: We observed SST neuron activation causing local neural inhibition, resulting in negative BOLD-fMRI at projection sites. Additionally, it triggered initial NO-induced fast vasodilation, followed by astrocyte-mediated slow vasodilation.
Impact: BOLD-fMRI reflects neural activity changes, yet certain interneurons induce hemodynamic responses without altering neural activity. Studying SST-induced responses is vital for interpreting fMRI.
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