Keywords: fMRI Analysis, fMRI (resting state), High-Field MRI
Motivation: GRE-EPI, the most widely used sequence for BOLD fMRI, is highly biased towards large draining veins that follow the cortical curvature and influence the surrounding magnetic field in an orientation-dependent manner increasing with field strength.
Goal(s): This work aims to investigate large vein biases resulting in cortical orientation-dependent signal variations in GRE-EPI and bSSFP resting-state fMRI signals.
Approach: We compared 2D and 3D GRE-EPI with 3D bSSFP rs-fMRI signal fluctuations in their dependence on the cortical orientation to B0 in five subjects at 9.4 Tesla.
Results: Unlike GRE-EPI, intra- and inter-subject comparisons revealed no dependence of bSSFP on the cortical orientation to B0.
Impact: Fluctuations in the GRE-EPI signal are highly dependent on the cortical orientation and depth. This was not observed with bSSFP, demonstrating the potentially higher specificity of bSSFP for smaller veins, closer to brain activation at field strengths ≥ 7 Tesla.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords