Keywords: Task/Intervention Based fMRI, Data Analysis, activation mapping
Motivation: The nonlinear nature of neurovascular coupling and background brain activities that are unrelated to extrinsic stimuli in tasks could result in an inadequate mapping of the task-evoked brain activations with the conventional-GLM in fMRI.
Goal(s): The aim of this study is to propose a new approach to map task-evoked brain activation without the linear assumption.
Approach: we proposed a model-free approach to map task-evoked activation in the whole brain by measuring increases in BOLD signal synchronization within anatomical structures.
Results: Compared to the GLM approach, the model-free approach could detect regions of brain activations beyond the conventional-GLM's characterization, especially in the white matter.
Impact: The model-free approach detects task-evoked brain activations by measuring changes in BOLD signal synchronization within local anatomical structures, which is expected to serve as a standardized tool to measure neural activities with nonlinear hemodynamic responses.
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