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Abstract #0382

Explaining Deep fMRI Classifiers with Diffusion-Driven Counterfactual Generation

Hasan Atakan Bedel1,2 and Tolga Çukur1,2,3
1Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 3Neuroscience Program, Bilkent University, Ankara, Turkey

Synopsis

Keywords: AI Diffusion Models, Machine Learning/Artificial Intelligence, fMRI, xAI, diffusion, transformers

Motivation: Deep-learning classifiers for functional MRI (fMRI) offer state-of-the-art performance in detection of cognitive states from BOLD responses, but their black-box nature hinders interpretation of results.

Goal(s): Our goal was to devise a reliable method to infer the important BOLD-response attributes that drive the decisions of deep fMRI classifiers.

Approach: We introduced a novel counterfactual explanation method (DreaMR) based on a new fractional, distilled diffusion prior for efficient generation of high-fidelity counterfactual samples.

Results: DreaMR generated more specific and plausible explanations of deep fMRI classifiers trained for resting-state and task-based fMRI analysis than previous state-of-the-art explanation methods.

Impact: The improvement in sensitivity, plausability and efficiency in explanation of deep classifiers through DreaMR may facilitate adoption of AI-based analyses in fMRI studies, thereby benefiting assessment of cognitive processes in both normal and neurological disease states.

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Keywords