Abstract #0404

Monitoring intranasal treatment to brain tumor using multiple CEST contrasts

Lok Hin Law¹, Haoyun Hin Su^1,2, Yang Hin Liu^1,2, and Kannie WY Hin Chan^1,2,3,4,5

¹Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, ⁵Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China

Synopsis

Keywords: Tumors (Post-Treatment), CEST & MT, Glioblastoma, Intranasal, Theranostic

Motivation: Theranostic application of intranasal drug delivery to glioblastoma using multiple CEST contrast.

Goal(s): Our goal is to monitor the drug delivery to brain tumor and evaluate the treatment effect simultaneously.

Approach: We investigated the imaging of liposome-based drug delivery to the brain tumor via intranasal administration,in which the amount of liposome and the tumor response can be detected by CEST MRI at 3T.

Results: CEST contrast at 3.5ppm of tumor region and the tumor size comparison between treatment and control group could indicate the therapeutic effect.CEST contrast at 4.3and-3.5ppm from pre-injection to post-injection in-vivo,could indicate the liposome drug delivery efficacy and drug distribution.

Impact: CEST MRI guided intranasal drug delivery could provide valuable information for assessing efficacy of drug delivery and treatment outcome. This can potentially translate to clinics as a non-invasive theranostic approach for glioblastoma treatment.

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