Abstract #0405

Application of accelerated quantitative magnetic resonance imaging in predicting drug resistance in pituitary prolactinomas

Rong Lu¹, Lijin Ji², Weijun Tang¹, Qing Li³, Caixia Fu⁴, Ying-Hua Chu³, Zheyuan Wu⁵, Tobias Kober^6,7,8, Tom Hibert^6,7,8, Shangxuan Shi⁹, and Tingfang Hwang¹

¹Radiology, Huashan Hospital, Fudan University, Shanghai, China, ²Endocrinology, Huashan Hospital, Fudan University, Shanghai, China, ³MR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China, ⁴Application Developments, Siemens Shenzhen Magnetic Resonance Ltd., 518057 Shenzhen, China, Shanghai, China, ⁵Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China, ⁶LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁷Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁸Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ⁹ShanghaiTech University, Shanghai, China

Synopsis

Keywords: Tumors (Post-Treatment), Endocrine, Pituitary prolactinoma

Motivation: Predicting and managing dopamine agonists (DA) resistance of prolactinomas remain a challenge. There is no reliable quantitative imaging marker.

Goal(s): The goal is to use accelerated quantitative T2 mapping(GRAPPATNI) for early diagnosis of drug resistance in pituitary prolactinomas to guide treatment.

Approach: This is a cross-sectional study. It will analyze the differences in T2 values between drug-resistant and sensitive groups and explore their diagnostic value in predicting drug sensitivity.

Results: Quantitative T2 values have better sensitivity than T2 signal intensity (SI) in predicting drug resistance in pituitary prolactinoma.

Impact: This is the first study to apply GRAPPATINI in prolactinoma. We found that T2 values of tumors were lower in drug-resistant prolactinoma than sensitive patients. T2 values might be a promising predictive imaging tool.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.