Keywords: Breast, Breast, CEST, Biomarkers, Cancer, Tissue Characterization
Motivation: CEST-MRI could provide biochemical and molecular information on breast lesions before detection of physiological and anatomical changes.
Goal(s): Our goal is to identify suitable in vivo CEST-MRI biomarker candidates.
Approach: 12 patients with 6 benign and 8 malignant lesions (pathology confirmed) who had concurrent CEST-MRI, transcriptome, and metabolomic data were included.
Results: Expression of several genes and metabolites correlated with MTRasym values (P<0.05) at 1, 2, and 3.5 ppm. At 1 and 2 ppm, DNA damage, cell cycle, stress response, and small molecule metabolic processes were prominently represented. Specific metabolites (e.g., Citrate/Isocitrate, glucuronate) showed significant correlations at 1, 2, and 3.5 ppm.
Impact: In vivo CEST-MRI parameters are reflective of transcriptome and metabolomic features in breast lesions. This provides molecular information, potentially before the detection of physiological and anatomical changes, and could facilitate accurate prediction of response to therapy allowing earlier interventions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords