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Abstract #0429

Longitudinal Changes of Hepatic Mechanical Properties in Patients with Early-Stage HCV Infection Treated with Direct-Acting Antiviral Agents

Caixin qiu1, Nana K Owusu1, Kevin J Glaser1, Jiahui Li1, Hao Wu1, Sudhakar K Venkatesh1, Douglas A Simonetto2, Ehman L Richard1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Liver, Elastography, HCV, loss modulus, damping ratio

Motivation: While DAAs have significantly improved the treatment of HCV patients, some individuals still face relapse or progression. There is currently a deficiency in non-invasive and simple methods for effectively monitoring the longitudinal treatment effects.

Goal(s): To develop a reliable biomarker for detecting inflammatory response to DAA treatment in the early stages of HCV infection.

Approach: Longitudinal monitoring of changes in early-stage HCV patients after DAA treatment using multiparametric MRE.

Results: Multi-parameter MRE can detect HCV at the early stage and can monitor both short-term inflammatory response and long-term treatment effect of the liver in HCV patients after DAA treatment.

Impact: Developed a non-invasive biomarker for monitoring the efficacy of DAA treatment in early-stage HCV patients.

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