Abstract #0437

Distinct functional connectivity of anterior cingulate cortex subregional networks in first-episode and recurrent major depressive disorder

Zilin Zhou¹, Lingxiao Cao¹, Yingxue Gao¹, Weijie Bao¹, Mengyue Tang¹, Hailong Li¹, Lianqing Zhang¹, Huaiqiang Sun^1,2, Qiyong Gong³, and Xiaoqi Huang^1,2

¹Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, ²Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, ³Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China

Synopsis

Keywords: Psychiatric Disorders, fMRI (resting state), major depresive disorder

Motivation: The fine-grained anterior cingulate cortex (ACC) subregional functional connectivity alterations in first-episode and recurrent major depressive disorder (MDD) remained unclear.

Goal(s): To obtain optimal functional ACC subdivisions and explore alterations in intrinsic functional connectivity of ACC subregional networks in first-episode and recurrent MDD.

Approach: We utilized a data-driven connectivity-based parcellation to obtain optimal ACC subdivisions, calculated ACC subregional functional connectivity, and compared among first-episode, recurrent MDD patients and healthy controls.

Results: Ventral and dorsal ACC per hemisphere were identified as optimal parcellation. The ACC subregional connectivity was reduced in all MDD patients, while dorsal ACC connectivity was significantly reduced only in recurrent patients.

Impact: Our discovery of impaired functional architectures of ACC subdivisions in MDD, with a more prominent disrupted connectivity of dorsal ACC in relapsed patients, emphasize a potential role of ACC subregional connectivity in distinguishing MDD at different episodes and predicting relapse.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.