Keywords: Bone, Bone, MSK, Quantitative Imaging, MR Fingerprinting, Data Processing
Motivation: Bone porosity is crucial for bone strength, yet standard multi-echo uTE-GRE techniques are too time-consuming for clinical use. uTE MR Fingerprinting (MRF) has not been tested for porosity assessment. If feasible it may offer faster porosity mapping for clinical applications.
Goal(s): Assessing the feasibility of using dual-echo 3D-uTE-MRF to measure porosity through simulations and preliminary in vivo testing.
Approach: A dual-echo 3D-uTE-MRF sequence was tested for porosity accuracy and precision against standard multi-echo uTE-GRE via simulations. In-vivo, a volunteer's tibia was imaged to demonstrate the technique's preliminary viability.
Results: In simulations, dual-echo uTE-MRF outperformed uTE-GRE, but in-vivo applications, despite feasibility, need further development.
Impact: We demonstrated the feasibility of a dual-echo uTE MRF approach for measuring bone porosity trough simulation and a preliminary in-vivo acquisition.
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