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Abstract #0517

Quantitative MRI of cartilage in ACL reconstructed patients using 3D ultrashort echo time T1 (UTE-T1) and magnetization transfer ratio (UTE-MTR)

Bhavsimran S Malhi1, Livia T Silva1, Melissa L Silva1, Jiyo S Athertya1, Dina Moazamian1, Yajun Ma1, Saeed Jerban1, Eric Y Chang1, Susan V Bukata1, Dana C Covey1, Christine B Chung1, and Jiang Du1
1University of California, San Diego, San Diego, CA, United States

Synopsis

Keywords: Cartilage, Quantitative Imaging

Motivation: Post traumatic osteoarthritis is a common complication of ACL injury. There is limited research on the early degenerative changes in cartilage of ACL injured knees.

Goal(s): To develop novel biomarkers for identifying early cartilage damage in ACL reconstructed knees.

Approach: We employed ultrashort echo time magnetization transfer ratio (UTE-MTR) and UTE-T1 sequence to study the knee articular cartilage in ACL reconstructed patients.

Results: UTE-T1 and UTE-MTR can be used as quantitative biomarkers for assessing cartilage damage. Reduced MTR and increased T1 values indicate cartilage damage which is otherwise not appreciated on morphological imaging.

Impact: UTE-T1 and UTE-MTR sequences can detect early cartilage damage, which could help us better understand the development of post-traumatic osteoarthritis.

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