Keywords: Elastography, Elastography
Motivation: Abnormal changes in myocardial stiffness during the cardiac cycle are a potential biomarker for cardiac diseases. However, there is currently no established MR-method for time-resolved mapping of cardiac stiffness.
Goal(s): To demonstrate the reproducibility of time-resolved stiffness mapping of the in-vivo human heart over the cardiac cycle by MR elastography (MRE).
Approach: Eleven healthy volunteers were examined twice using multifrequency cardiac-triggered, segmented gradient echo spiral MRE for stiffness mapping of the left ventricular myocardium in a short-axis view.
Results: Excellent, good, and moderate reproducibility was achieved for isovolumetric contraction, systolic, and diastolic phases, respectively. Significant differences among all phases were apparent.
Impact: The achieved high reproducibility of cardiac multifrequency MRE, together with its ability to identify distinct time-resolved stiffness levels during the cardiac phases of isovolumetric contraction, systole and diastole, could potentially detect stiffness related cardiac pathology in early disease stages.
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