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Abstract #0572

Influence of fat droplet size on liver R2* relaxometry by Monte Carlo simulation and phantom studies

Xiaoben Li1, Tingmiao Wu2,3, Scott B. Reeder4,5,6,7,8, Diego Hernando4,5, and Changqing Wang1
1School of Biomedical Engineering, Anhui Medical University, Hefei, China, 2Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China, 3Anhui Public Health Clinical Center, Hefei, China, 4Department of Radiology, University of Wisconsin, Madison, WI, United States, 5Department of Medical Physics, University of Wisconsin, Madison, WI, United States, 6Department of Biomedical Engineering, University of Wisconsin, Madison, WI, United States, 7Department of Medicine, University of Wisconsin, Madison, WI, United States, 8Department of Emergency Medicine, University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Quantitative Imaging, Liver, R2*; fat droplet size; Monte Carlo simulations; phantom

Motivation: Liver fat (hepatic steatosis) can confound R2*-based iron quantification in chemical shift encoded MRI, while the size of fat droplets may also affect liver R2*. However, it is infeasible to experimentally investigate the influence of fat droplet size in vivo on liver R2* due to tissue complexity.

Goal(s): To investigate the influence of fat droplet size on liver R2* at both 1.5T and 3.0T.

Approach: Monte Carlo simulation and phantom studies.

Results: Liver R2* demonstrates a positive linear relationship with proton density fat fraction and remains relatively unaffected by fat droplet size.

Impact: These findings may benefit phantom design and understanding of the underlying mechanisms of R2* characteristics in the presence of hepatic steatosis.

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Abstract

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