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Abstract #0575

Accelerated Preclinical UHF Abdominal T1 Mapping using Novel Rosette Ultrashort Echo Time (PETALUTE)

Alexandra Lipka1,2,3, Stephen Sawiak4,5, Xin Shen6, Uzay Emir1,7, Ali Özen8, Mark Chiew9,10,11, Joseph Speth1, Deng-Yuan Chan1, Zhen Jiang1, Gregory Tamer Jr.7, and Matthew Scarpelli1
1School of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States, 2College of Engineering, Purdue University, West Lafayette, IN, United States, 3High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom, 5Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, 6Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 7Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 8Department of Radiology, Medical Physics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 9Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 10Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 11Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Preclinical Image Analysis, Preclinical, Abdomen, T1 Mapping

Motivation: Well established techniques for fast 3D T1 mapping with cartesian/radial trajectories are prone to respiratory artifacts.Previously established non-cartesian sequences have mitigated the influence of motion artifacts, though still suffer from long measurement times.

Goal(s): Implementation of a novel 3D dual-echo rosette k-space trajectory for preclinical UTE MRI(PETALUTE) for abdominal imaging of both anatomical and quantitative T1 measurements and retrospective 4-fold acceleration.

Approach: PETALUTE(resolution 0.24x0.24x0.24mm3,accelerated scan-time 2:15min) acquisition for T1 mapping via variable flip angle method and evaluation of T1 values and acceleration effects.

Results: High-resolution non-gated abdominal imaging with the ability to clearly distinguish anatomy and T1 values,that did not deprecate when accelerated.

Impact: Well established methods for T1 mapping using cartesian/radial trajectories suffer from motion artifacts due to long acquisition duration.PETALUTE,a novel 3D dual-echo rosette k-space trajectory for preclinical UTE-MRI,is able to generate high-resolution non-gated abdominal anatomical images and T1 mapping in ~2min.

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Abstract

Keywords