Keywords: Simulation/Validation, Phantoms
Motivation: We aim to create a universal procedure for experimental verification of diffusion models using model systems based on glass capillaries.
Goal(s): Spatially ordered glass capillaries mimics the characteristic geometry of white matter and are ideal for performing a 'stress test' of various diffusion models. We aim to verify this through diffusion and relaxation measurements at varying spatial directions and time scales.
Approach: Combined diffusion- and relaxation-weighted MRI based measurements verify the geometry of the glass capillaries at different spatial scales.
Results: The glass capillary phantom was established as a ground truth model for modelling of white matter at different diffusion and relaxation regimes.
Impact: Glass capillaries present a unique object with simple physical and geometrical features mimicking white matter. We tested a glass capillary phantom in terms of a diffusion-relaxation model using conventional sequences and provide a simple theoretical interpretation of experimental results.
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