Meeting Banner
Abstract #0594

Spatial Imaging Transcriptomic reveals the molecular basis among diffusion MRM models

Yiqi Shen1, Yao Shen1, Zuozhen Cao1, Sihui Li1, Guojun Xu1, Zhiyong Zhao1, and Wu Dan1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, Hangzhou, China

Synopsis

Keywords: Microstructure, Microstructure, Spatial Imaging Transcriptomic;Data Integration;Mouse Brain

Motivation: Integration of MRI and spatial transcriptomics may provide a new approach for imaging-genetics research for probing molecular basis underlying observed MRI phenotypes.

Goal(s): We proposed a pipeline for integration of diffusion MRI(dMRI) and spatial transcriptomics of mouse brain to understand potential biological pathway underlying dMRI microstructural models.

Approach: We spatially co-register population-averaged dMRI maps of mouse brain to 2D spatial transcriptomic for pixelwise correlation and explored genes function and celltype related with dMRI metrics.

Results: We found FA was associated with myelination and oligodendrocyte and water diffusivity was associated with neurons. We identified molecular basis driving two distinct gradients of dMRI in cortex.

Impact: Integration of spatial transcriptomics and MRI enables imaging-genomics analysis at an unprecedented resolution. Our study revealed molecular basis for typical microstructural markers in diffusion MRI. We further revealed genetic driven force of cortical gradients in axial and radial diffusivity maps.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords