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Abstract #0616

Complex B1+ field-based conductivity mapping in the human myocardium at 3T

Paulina Siuryte1, Thierry Meerbothe2, Yi Zhang1, Markus Henningson3, Joao Tourais1, Christal van de Steeg-Henzen4, Qian Tao1, Stefano Mandija2, and Sebastian Weingärtner1
1TU Delft, Delft, Netherlands, 2UMC Utrecht, Utrecht, Netherlands, 3Linköping University, Linköping, Sweden, 4Holland PTC, Delft, Netherlands

Synopsis

Keywords: Myocardium, Electromagnetic Tissue Properties, electrical properties, conductivity, parametric mapping, cardiac, EPT

Motivation: While electrical property tomography is gaining popularity, cardiac applications are limited due to inadequate cardiac B1+ mapping. Thus, conductivity mapping in the heart using complex B1+ maps is yet unexplored.

Goal(s): To measure myocardial conductivity from the complex B1+ distribution in the heart at 3T.

Approach: A novel |B1+| mapping method was adapted for free-breathing B1+ maps, followed by conductivity reconstruction via 1D polynomial fitting in saline phantoms and four healthy subjects.

Results: Phantom results show excellent correlation with expected values (R2=0.95). In-vivo, conductivity is largely homogenous with 0.69±0.13S/m average in-plane conductivity across all subjects, in line with the literature.

Impact: Electrical properties are a valuable biomarker, however, the translation to cardiac imaging remains limited. In this work, complex B1+ field-based conductivity is reported in the human myocardium at 3T, using a novel Bloch-Siegert shift-prepared cardiac B1+ mapping technique.

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