Abstract #0625

Rapid Pediatric Imaging with Zero-Shot Deep Subspace Reconstruction for Multiparametric Quantitative MRI

Yohan Jun^1,2, Shohei Fujita^1,2, Jaejin Cho^1,2,3, Xingwang Yong^1,2,4, Eugene Milshteyn⁵, Camilo Jaimes^2,3,6, Suely Fazio Ferraciolli^2,3,6, Borjan Gagoski^2,7, Michael S Gee^2,3,6, and Berkin Bilgic^1,2,8

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Pediatric Imaging Research Center, Massachusetts General Hospital, Boston, MA, United States, ⁴Zhejiang University, Hangzhou, China, ⁵GE Healthcare, Boston, MA, United States, ⁶Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁷Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, ⁸Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States

Synopsis

Keywords: Quantitative Imaging, Pediatric, Quantitative Imaging

Motivation: To address unmet needs for accurate, rapid, and high-fidelity quantitative MRI using a 3D-QALAS sequence.

Goal(s): To enable accurate T₁ and T₂ mapping with reduced biases, g-factor noise amplification, and relaxation-related blurring compared to conventional QALAS.

Approach: We employed a zero-shot self-supervised subspace reconstruction technique, Zero-DeepSub, which combines scan-specific deep-learning-based reconstruction with low-rank subspace modeling, and demonstrated the performance using ISMRM/NIST phantom and pediatric patients.

Results: Zero-DeepSub enabled a highly accelerated, 2 min acquisition at 1 mm isotropic resolution at 3T, as well as a 5 min pediatric exam at 1.2 mm isotropic resolution at 1.5T.

Impact: Zero-DeepSub enabled accurate T₁ and T₂ mapping with reduced biases, g-factor noise amplification, and relaxation-related blurring, showing the potential to substantially speed up pediatric brain exams, thus obviating the need for or reducing the amount of sedation and anesthesia.

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