Abstract #0634

Quantitative analysis of induced tendon degeneration using magic angle insensitive ultra-short echo time magnetization transfer

Georg C Feuerriegel¹, Adrian A Marth^1,2, Sophia S Goller¹, Monika Hilbe³, Reto Sutter¹, and Stefan Sommer^4,5

¹Department of Radiology, Balgrist University Hospital, Zurich, Switzerland, ²Swiss Center for Musculoskeletal Imaging, Balgrist Campus, Zurich, Switzerland, ³Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland, ⁴Swiss Center for Musculoskeletal Imaging (SCMI), Balgrist Campus, Zurich, Switzerland, ⁵Advanced Clinical Imaging Technology (ACIT), Siemens Healthineers International AG, Zurich, Switzerland

Synopsis

Keywords: Tendon/Ligament, Tendon/Ligament

Motivation: Ultra-short echo time (UTE) imaging combined with magnetization transfer (MT) allows for magic angle effects (MAE)-insensitive quantification of short T2 tissues, but clinically feasible applications are rare.

Goal(s): The objectives of this study were to qualitatively and quantitatively assess changes in bovine flexor tendons before and after collagen degradation.

Approach: 3D UTE MT imaging was compared to UTE T2* mapping at 0°, 27°, 55° and 90° relative to the B₀ field within a clinically feasible acquisition time.

Results: Compared to UTE T2* mapping, UTE MT imaging was significantly less affected by the MAE and demonstrated a better performance in differentiating partial tendon tears.

Impact: UTE MT imaging is a reliable and reproducible method for quantifying tendon degeneration that is robust to the magic angel effect, acquired within a clinically feasible scan time, and could therefore be a useful tool in the diagnosis of tendinopathies.

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