Keywords: Other Neurodegeneration, Neurodegeneration, non-proton; sodium; ALS
Motivation: ALS is a neurodegenerative disease leading to progressive motor deficit and death within few years. There is an unmet need to identify non-invasive biomarkers at the individual level to predict disease progression.
Goal(s): To study disease severity at the individual level in ALS by mapping abnormal sodium homeostasis using brain 23Na-MRI.
Approach: 27 ALS patients were explored by brain 23Na-MRI. Individual map of abnormal total sodium concentration (TSC) was computed for each patient compared to a local database of 62 controls.
Results: This study mapping sodium homeostasis disturbances at the individual level in ALS patients evidenced association between TSC increase and disease severity.
Impact: This pilot study mapping sodium homeostasis disturbances at the individual level in ALS patients through 23Na-MRI evidenced association between TSC increase and disease severity and may be a future biomarker to help stratifying patients and evaluating new therapeutics.
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