Keywords: Other Neurodegeneration, Aging, LATE, Alzheimer’s, Neuropathology, Aging, Postmortem MRI
Motivation: Alzheimer’s disease neuropathologic change (AD-NC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common age-related pathologies and are associated with brain atrophy, especially in the medial temporal lobe. However, the difference in atrophy patterns associated with the two pathologies is not well known.
Goal(s): To investigate the difference in brain atrophy patterns associated with AD-NC and LATE-NC.
Approach: Ex-vivo MRI and detailed neuropathology were combined in a large number of community-based older adults that came to autopsy.
Results: LATE-NC stages 2 or 3 are associated with more atrophy in the anterior portion of the hippocampus compared to moderate or severe AD-NC.
Impact: Atrophy in the anterior portion of the hippocampus is more severe with LATE-NC stages 2 or 3 than with moderate or severe AD-NC.
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