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Abstract #0668

Brain arterial remodeling and incident dementia: the Atherosclerosis Risk in Communities (ARIC) Study

Sile Wang1, Melissa Caughey2, Ziyang Xu1, Xinwei Zhou1, and Ye Qiao1
1Deptartment of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Deptartment of Biomedical Engineering, University of North Carolina & North Carolina State University, Chapel Hill, NC, United States

Synopsis

Keywords: Dementia, Blood vessels, MRA

Motivation: We aimed to address the gap in understanding the neurovascular contributions to dementia risk in a US community-based study, recognizing the need to consider arterial geometry factors and cerebral small vessel disease (CSVD).

Goal(s): Our study sought to investigate the relationship between brain arterial remodeling and incident dementia risk, focusing on how arterial geometry and CSVD factor into this complex equation.

Approach: Our approaches involved analyzing data from a US community-based study to assess the impact of arterial remodeling, arterial geometry, and CSVD on dementia risk.

Results: Our study's core findings indicate an increased risk of incident dementia associated with brain arterial remodeling.

Impact: Our model is promising for the prediction of cognitive decline and dementia diagnosis based on the MRA measurements.

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