Abstract #0693

Common coordinate framework of infant marmoset brain based on ultra-high-resolution diffusion MRI

Tianjia Zhu^1,2, Juri Kim^1,2, Fengxia Wu^1,3, Minhui Ouyang^1,4, Andre Sousa⁵, Jon Levine⁵, Arnold Kriegstein⁶, and Hao Huang^1,4

¹Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Anatomy and Neurobiology, Shandong University, Jinan, China, ⁴Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Anatomy and Neurobiology, University of Wisconsin - Madison, Madison, WI, United States, ⁶Department of Neurology, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Large Animals, Nonhuman Primates, Normal development, normal development, large animals-nonhuman primates, ultra-high resolution diffusion MRI, common coordinate framework

Motivation: Integrating a spatially resolved and molecularly defined cell atlas with studies of developing brain function, neurophysiology, and behavior will require an anatomical common coordinate framework (CCF). Ultra-high-resolution diffusion-MRI (dMRI) improves anatomical determinations and provides rich contrasts and microstructural information.

Goal(s): To build the first dMRI-based anatomical CCF for infant marmoset brains.

Approach: Ultra-high resolution dMRI at 9.4T was performed on a 10-month-old marmoset brain. Anatomical regions were delineated.

Results: An ultra-high-resolution CCF for the infant marmoset brain at isotropic 0.1mm diffusion MR imaging resolution, characterized by comprehensive labels of fine neuroanatomical structures and coordinate framework.

Impact: The first infant marmoset brain CCF will allow integrating spatially resolved, molecularly defined cell atlas with studies of developing brain function, neurophysiology, and behavior. It will provide insights into evolution and human-specific features of brain development relevant to brain disorders.

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