Abstract #0699

Biophysical analysis of hepatocellular carcinoma and tumor niche in an orthotopic mouse model with diffusion MRI and MR elastography

Pedro Augusto Dantas de Moraes¹, Yasmine Safraou¹, Karolina Krehl², Tom Meyer¹, Akvile Häckel¹, Eyk Schellenberger¹, Anja Kühl³, Jürgen Braun⁴, Lynn Jeanette Savic¹, Ingolf Sack¹, and Jing Guo¹

¹Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Department of Veterinary Medicine, Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Freie Universität Berlin, Berlin, Germany, ³iPATH.Berlin, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴Institute of Medical Informatics, Charité – Universitätsmedizin Berlin, Berlin, Germany

Synopsis

Keywords: Preclinical Image Analysis, Elastography, Cancer, HCC

Motivation: The biomechanical interplay between hepatocellular carcinoma (HCC) and the hosting liver is poorly understood.

Goal(s): To characterize the development of HCC and its interactions with the surrounding liver using imaging-based biophysical properties.

Approach: We investigated longitudinally HCC and the host liver in an orthotopic mouse model using MR elastography (MRE) and diffusion-weighted imaging (DWI).

Results: During tumor development, the host liver became softer with reduced viscosity and restricted water diffusivity while HCC became stiffer, less viscous and restricted water diffusivity.

Impact: Preclinical MRE is a useful tool to study biomechanical properties of tumors and the tumor environment. In a mouse model of hepatocellular carcinoma, we showed for the first time how liver tumors shape their biomechanical niche in the hosting liver.

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