Keywords: Probes & Targets, Tumor
Motivation: gadolinium widely used in MRI clincally show low detecting efficiency for early pancreatic cancer(<2 cm). It is thus urgent to develop safe and effective contrast agents to address this issue.
Goal(s): This study aims to investigate the potential of cancer cell membrane coated Mn(II) nanoprobes (PMNP@CMs) in MRI for precise diagnosis of early pancreatic cancer.
Approach: PMNP@CMs were prepared for MRI of pancreatic cancer to explore the imaging effects in vivo and in vitro compared with gadolinium.
Results: PMNP@CMs showed more predominant MRI effect than gadolinium and may be considered as safe and efficient contrast agents to realize diagnosis for early pancreatic cancer.
Impact: This work has developed a nano magnetic resonance imaging contrast agent (PMNP@CMs) that is more advantageous than gadolinium and can achieve precise diagnosis of early pancreatic cancer.
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