Abstract #0732
ASL blood-brain barrier permeability is associated with amyloid and cognitive impairment
Beatriz E. Padrela1, Sandra Tecelão2, Oliver Geier3, Markus H. Sneve4, David Vallez Garcia1, Amnah Mahroo5, Lene Pålhaugen2,6, Bjørn-Eivind Kirsebom6,7, Klaus Eickel5, David L. Thomas8, Atle Bjørnerud4,9, Anders M. Fjell4,10, Kristine B. Walhovd4, Frederik Barkhof1, Per Selnes2, Matthias Günther5, Jan Petr11, Tormod Fladby2, and Henk J.M.M. Mutsaerts1
1Radiology and Nuclear Medicine, Amsterdam UMC locatie VUmc, Amsterdam, Netherlands, 2Department of Neurology, Akershus University Hospital, Oslo, Norway, 3Department of Physics and Computational Radiology, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 4Department of Psychology, Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway, 5Fraunhofer-Institute for Digital Medicine MEVIS, Bremen, Germany, 6Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway, 7Department of Neurology, University Hospital of North Norway, Tromsø, Norway, 8Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 9Oslo University Hospital, Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo, Norway, 10Computational Radiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 11Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany
Synopsis
Keywords: Alzheimer's Disease, Arterial spin labelling, Blood-brain barrier, Biomarkers
Motivation: Blood-brain barrier (BBB) permeability changes may be implicated in Alzheimer’s Disease (AD) pathophysiology.
Goal(s): To investigate if the exchange time (Tex) of water across the BBB is associated with cognitive and amyloid status.
Approach: We measured Tex with a multi-echo arterial spin labeling MRI sequence in 116 adults older than 50 years and studied its association with cognition (cognitively normal vs mild cognitive impaired) and amyloid (A- vs A+) status.
Results: BBB water permeability is increased in A+ participants and in patients with MCI, compared to healthy controls
Impact: Our results suggest that multi-TE ASL MRI BBB water permeability can be used as a potential early imaging biomarker of AD pathophysiology.
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