Keywords: Multiple Sclerosis, Multiple Sclerosis, Brain Lymphatics
Motivation: Multiple sclerosis (MS) involves a proinflammatory state leading to cellular waste accumulation and disability. This study investigates the glymphatic system's waste clearance role, hypothesizing that lymphatic dysfunction contributes to MS-related disability.
Goal(s): Explore the relationship between glymphatic function, meningeal lymphatic vessels (mLV), and MS-related disability.
Approach: The study examined 49 MS patients using MRI to visualize mLVs and evaluate glymphatic stasis via CSF fraction (CSFF), analyzing links between mLV volume, CSFF, and MS outcomes
Results: With age, cortical CSFF increases. mLV volume also increases with CSFF. Higher cortical CSFF is associated with more lesions and disability, suggesting glymphatic dysfunction contributes to MS-related disability.
Impact: Our study suggests that glymphatic dysfunction contributes to lesion burden and disability in multiple sclerosis, highlighting the importance of lymphatic clearance mechanisms in disease progression.
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