Abstract #0763

Thalamic nuclei atrophy in autosomal dominant Alzheimer's disease

Manojkumar Saranathan¹, Elizabeth Kaplan², Michael Hornberger³, Ana Baena⁴, Diana Munera², Justin Sanchez², Stephanie Langella², Francisco Lopera⁴, and Yakeel Quiroz⁵

¹Radiology, University of Massachusetts Chan Medical School, Worcester, MA, United States, ²MGH, Harvard Medical School, Charlestown, MA, United States, ³Norwich Medical School, University of East Anglia, East Anglia, United Kingdom, ⁴Neurociencias, Universidad de Antioquia, Medellin, Colombia, ⁵Psychiatry, MGH, Harvard Medical School, Charlestown, MA, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, thalamic nuclei segmentation

Motivation: The thalamus has not been investigated properly in autosomal dominant Alzheimer's disease (ADAD) despite evidence of early involvement.

Goal(s): We investigated thalamic nuclei atrophy in asymptomatic presenilin carriers vs. non-carriers in an ADAD cohort using a recently proposed multi-atlas segmentation method.

Approach: Thalamic nuclear atrophy and correlations of nuclei volumes with age, amyloid, and tau burden were
analyzed in mutation carriers vs. non-carriers in an ADAD cohort.

Results: Significant atrophy was seen in mediodorsal, pulvinar, and medial geniculate nuclei in carriers compared to non-carriers. These nuclear volumes correlated significantly with age, amyloid, and tau burden as well.

Impact: The pattern of thalamic nuclear atrophy in ADAD presenilin mutation carriers can help understand mechanisms for disease progression as well as aid in possible treatment targets.

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