Abstract #0765

Automated VOI analysis of amyloid PET-MRI

Yasutaka Fushimi¹, Satoshi Nakajima¹, Sachi Okuchi¹, Akihiko Sakata¹, Sayo Otani¹, Azusa Sakurama¹, Hiroshi Tagawa¹, Yang Wang¹, Satoshi Ikeda¹, Shuichi Ito¹, Masaaki Umehana¹, Yongping Ma¹, Katsuhiko Mitsumoto², Manabu Kubota³, Atsushi Shima⁴, Nobukatsu Sawamoto⁵, and Yuji Nakamoto¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Department of Clinical Radiology Service, Kyoto University Hospital, Kyoto, Japan, ³Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Department of Regenerative Systems Neuroscience, Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan

Synopsis

Keywords: Software Tools, PET/MR, Amyloid

Motivation: Automated analysis of amyloid PET becomes available, however, these results have not been well analyzed on PET/MRI.

Goal(s): To compare the reference regions and VOIs associated with amyloid positivity between the software and Centiloid project on Amyloid PET/MRI.

Approach: We analyzed Amyloid PET/MRI data of 84 subjects automatically and values, SUVr, Centiloid scale were compared.

Results: The reference VOIs and VOIs associated with amyloid positivity showed good correlation between the software and Centiloid project.

Impact: The values obtained with the automated software on amyloid PET/MRI can be utilized with the other quantitative MR data, which may lead to comprehensive analysis of amyloid deposition.

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