Abstract #0775

Temporal response of T2 and adiabatic T1ρ and T2ρ relaxation times to acute ischemic injury to the femoral head: an in vivo piglet model study

Casey P. Johnson^1,2, Erick O. Buko^1,2, Suhail Parvaze^1,2, Douglas Albrecht¹, Alaina L. Falck¹, Alexandra R. Armstrong¹, Jennifer C. Laine^3,4, and Ferenc Toth¹

¹Department of Veterinary Clinical Sciences, University of Minnesota, Saint Paul, MN, United States, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ³Gillette Children's Specialty Healthcare, Saint Paul, MN, United States, ⁴Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Bone, Ischemia

Motivation: Relaxation time mapping may be clinically useful to inform the severity of ischemic injury to bone marrow in osteonecrosis of the femoral head.

Goal(s): To compare the temporal response of T2, adiabatic T1ρ, and adiabatic T2ρ mapping to acute ischemic injury to the femoral head.

Approach: 24 piglets were imaged using 3D relaxation time mapping at 3T MRI before and after surgical induction of unilateral femoral head ischemia. Corresponding cellular changes were evaluated histologically.

Results: T2 and adiabatic T2ρ were the most sensitive in detecting acute injury to the femoral head, as early as 24 hours after onset of ischemia.

Impact: T2 and/or adiabatic T2ρ relaxation time mapping can potentially address a clinical need for a non-contrast-enhanced imaging technique to establish the severity and extent of bone marrow necrosis in the earliest stages of osteonecrosis of the femoral head.

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