Abstract #0780

Monitoring diabetic kidney disease progression with DTI and tractography

Joao Periquito¹, Kanishka Sharma^1,2, Kywe Soe¹, Bashair Alhummiany³, Jonathan Fulford⁴, David Shelley³, Mark Gilchrist⁴, Angela Shore⁴, Kim Gooding⁴, Michael Mansfield⁵, Maria Gomez⁶, and Steven Sourbron¹

¹The University of Sheffield, Sheffield, United Kingdom, ²Antaros Medical AB, Mölndal, Sweden, ³Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, ⁴University of Exeter Medical School, Exeter, United Kingdom, ⁵Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁶Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden

Synopsis

Keywords: Kidney, Kidney

Motivation: Previous studies have shown that DTI and tractography may act as early indicator of DKD.

Goal(s): The aim of this study was to identify DTI biomarkers that may be sensitive to changes over a relatively short 2-year time frame in early-stage DKD.

Approach: Thirteen type-2 diabetic patients were scanned two times during a two-year period on a 3T MRI scanner using a free-breathing diffusion protocol. 180 biomarkers from DTI and tractography were calculated with DIPY.

Results: 46 biomarkers showed a significant change over the 2 years, with mean changes that reach over ½ of a standard-deviation and cohen-d effect-sizes up to 0.6

Impact: DTI biomarkers show strong changes in early-stage diabetic kidney disease over 2-years, a time frame where clinical biomarkers are typically stable. This finding may have significant implications for clinical practice if confirmed in the larger population.

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