Abstract #0781
Multiparametric Renal MRI Reveals Ethnic Disparities in Multiple Kidney Function Markers in Asian Preadolescents
Navin Michael1, Liangjian Lu2, Delicia Shu Qin Ooi3, Chang-Yien Chan2,3, Kashthuri Thirumugan1, Yeshe Kway1, Suresh Anand Sadananthan1, Marielle Fortier4, Bernd Kuhn5, Mary Foong-Fong Chong6, Jia Ying Toh1, Kok Hian Tan7,8, Fabian Yap8,9,10, Yap Seng Chong11, Keith M Godfrey12, Peter Gluckman1,13, Johan G Eriksson1,11,14,15, Yung Seng Lee3, Karen Moritz16, Shiao-Yng Chan11, Mary Wlodek17,18, and S. Sendhil Velan1
1Agency for Science, Technology and Research (A*STAR), Singapore Institute for Clinical Sciences (SICS), Singapore, Singapore, 2Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore, 3Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 4Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, Singapore, 5Siemens Healthcare GmbH, Erlangen, Germany, 6Saw Swee Hock School of Public Health, National University of Singapore and National University Health System,, Singapore, Singapore, 7Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore, Singapore, 8Duke-NUS Medical School, Singapore, Singapore, 9Department of Pediatrics, KK Women's and Children's Hospital, Singapore, Singapore, 10Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, 11Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 12MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 13Liggins Institute, University of Auckland, Auckland, New Zealand, 1414Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, 15Folkhälsan Research Center, Helsinki, Finland, 16School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Australia, 17Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia, 18School of Molecular Sciences, The University of Western Australia, Crawley, Australia
Synopsis
Keywords: Kidney, Kidney, Volumetry, Diffusion, Perfusion, Oxygenation
Motivation: Within Singapore's multiethnic population, Indians and Malays have a higher burden of chronic kidney disease than Chinese. While this has been attributed to higher prevalence of hypertension, diabetes and dyslipidemia, it is not clear if Indians and Malays already have preexisting subclinical renal alterations.
Goal(s): Assess ethnic differences in kidney function markers in healthy Asian preadolescents using multiparametric MRI and physiological assessments.
Approach: Identify adverse renal function using multiparametric MRI (volumetry, diffusion, perfusion, oxygenation) and physiological assessments (urine albumin, estimated glomerular filtration rate, blood pressure)
Results: Indian and Malay preadolescents showed multiple renal alterations which predate the development of diabetes, hypertension or dyslipidemia.
Impact: Detailed renal phenotyping of Asian preadolescents using multiparametric renal MRI and physiological assessments identified ethnic disparities in multiple renal function markers, which predate the development of diabetes, hypertension or dyslipidemia, and may help explain the predisposition for chronic kidney disease.
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