Keywords: Neurofluids, Neurofluids, Glymphatic, MRI Velocimetry, Phase-Sensitive Diffusion
Motivation: To study glymphatic circulation in the brain parenchymal tissue, methods to measure sub-millimeter velocities of fluid flow in tissue must be developed.
Goal(s): We evaluate the feasibility of imaging both coherent and incoherent motion (SCIMI) in brain tissue using phase-sensitive reconstruction of dMRI.
Approach: Approach: By modifying a DTI sequence to achieve physiologically relevant low VENC, we demonstrate the simultaneous reconstruction of diffusion metrics highlighting incoherent motion in the brain and velocity data showing coherent motion by leveraging phase and magnitude information.
Results: We measure velocity maps in the whole brain in conjunction with clinically relevant diffusion metrics.
Impact: SCIMI acquisition and reconstruction of velocity in brain parenchymal tissue shows to be an important addendum that can be run parallel to existing DTI methods and provides novel insights into glymphatic circulation.
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