Keywords: Neurofluids, Neurofluids
Motivation: The impact of respiration on fluid flow in brain parenchyma is poorly understood and remains an on-going research topic in MRI velocimetry.
Goal(s): To analyze the sensitivity of the simultaneous coherent and incoherent motion imaging (SCIMI) method to respiratory-induced phase in the brain parenchyma and to regress this phase contribution from the underlying slow-flow-induced phase.
Approach: Prospectively cardiac-gated SCIMI acquisitions were obtained during three different breathing schemes.
Results: Existence of strong correlations (p<0.005) between the breathing profiles and measured phase in various brain regions indicated the presence of respiration-induced phase in the SCIMI acquisition, and regression of such phases showed promising results.
Impact: This study showed the sensitivity of simultaneous coherent and incoherent motion imaging method to respiration-induced phase in the brain, and an initial attempt to regress such phase accrual from the desired brain slow flows$$$–$$$an important biomarker of glymphatic function.
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