Keywords: Parkinson's Disease, Parkinson's Disease, Diffusion tensor image
Motivation: Glymhatic system as a therapeutic target for multiple system atrophy (MSA) lacks imaging markers.
Goal(s): Our goal was to determine changes in imaging parameters after human umbilical cord blood mononuclear cells (hUCB-MCs) transplantation.
Approach: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) of MSA patients were compared with healthy controls and the ALPS indices of patients were compared before and after hUCB-MCs transplantation.
Results: We found that MSA patients had lower ALPS values than health controls and that ALPS values increased after treatment.
Impact: Our demonstration of a detectable decline in MSA patients and an uptick after treatment utilizing ALPS metrics provides an imaging marker to monitor the glymphatic system after hUCB-MCs transplantation.
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